OS Version: Windows Server 2016

The only situation where you would want to do this would be if you already had an up to date and supported malware detection application installed. If you do not know or are unsure, I definitely do NOT recommend this.

Logged in as Administrator, bring up Powershell.

PS> Uninstall-WindowsFeature -Name Windows-Defender

PS> Restart-Computer -ComputerName “localhost”